Early Elevation of C-Reactive Protein Correlates with Severe Infection and Nonrelapse Mortality in Children Undergoing Allogeneic Stem Cell Transplantation

Jennifer L. McNeer, Morris Kletzel, Alfred Rademaker, Kavita Alford, Kathleen O'Day, Colleen Schaefer, Reggie Duerst, David A. Jacobsohn*

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

C-reactive protein (CRP) is an acute phase reactant that is a reliable marker of systemic inflammation and has been associated with increased morbidity and mortality following hematopoietic stem cell transplantation (HSCT) in adults. In this study, we evaluated whether early elevations of CRP were associated with various complications and nonrelapse mortality following HSCT in pediatric patients. Seventy pediatric patients had CRP levels drawn at regular time points during the first week following their transplants. Patients were followed for 100 days following transplant, and transplant-related complications were documented. Patients who subsequently developed severe infections had higher median CRP values than those without severe infections (median 8.03 mg/dL versus 1.64 mg/dL, P = .0008) as did those who suffered nonrelapse mortality compared with those who did not (12.6 mg/dL versus 2.44 mg/dL, P = .02). These findings suggest that elevated CRP values may be useful as a marker of individual pediatric patients with a higher risk for treatment-related morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Allogeneic transplant
  • C-reactive protein
  • Infection
  • Nonrelapse mortality
  • Pediatric

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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