Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?

Karen J. Ho, John Varga*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

10 Scopus citations

Abstract

Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models.

Original languageEnglish (US)
Pages (from-to)2253-2255
Number of pages3
JournalJournal of Investigative Dermatology
Volume137
Issue number11
DOIs
StatePublished - Nov 2017

Funding

Per journal regulations, we are restricted to a limited number of references. However, many original papers are cited in the listed review articles. We acknowledge partial support by grants from National Institutes of Health (K08 HL130601 to KJH and R56 AG054207 to JV).

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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