Early murine lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class Ii-Cd4+T cell interactions

Eric M. Ruderman, Janet S. Kerr, Sam R. Telford, Andrew Spielman, Laurie H. Glimcher, Ellen M. Gravallese

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

To compare the role of macrophages and CD4+T lymphocytes in early Lyme carditis, immunohistochemical techniques were used to analyze cardiac infiltrates in immunocompetent mice infected with Borrelia burgdorferi spirochetes. Macrophages predominated in the infiltrate during the first 4 weeks after infection. CD4+and CD8+lymphocytes each constituted < 5% of the infiltrate; B lymphocytes were rare. Infected mice deficient in class II major histocompatibility complex (MHC) antigen and depleted of CD4+lymphocytes developed similar infiltrates, suggesting that class II MHC-CD4+lymphocyte interactions do not playa critical role in disease initiation. Expression of mRNA encoding JE within areas of cardiac inflammation implicates this chemokine in the recruitment and activation of macrophages in this disease. These data demonstrate that early murine Lyme carditis requires neither class II antigen expression nor presentation of antigen to CD4+T lymphocytes and suggest a direct response of macrophages to cardiac tissue invasion by B. burgdorferi.

Original languageEnglish (US)
Pages (from-to)362-370
Number of pages9
JournalJournal of Infectious Diseases
Volume171
Issue number2
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

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