Early prenatal development of substance P and enkephalin‐containing neurons in the rat

Virginia M. Pickel*, Khushdev K. Sumal, Richard J. Miller

*Corresponding author for this work

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The peroxidase‐antiperoxidase (PAP) technique is used to determine the time of first detection and distribution of neuronal perikarya and processes showing substance P (SP)‐ and enkephalin (EN)‐like immunoreactivity (LI) in the central and peripheral nervous system of the fetal rat. SPLI is first detected in central perikarya at E15. By E18, SPLI is less intensely localized in certain nuclei and shows heavier accumulations of immunoreactivity in central processes in peripheral sensory neurons. ENLI is also widely distributed in perikarya and processes of the central nervous system at E18, but is not detected at E15. The distribution of SPLI and ENLI at E18 is comparable to that previously described in the adult brain with the following exceptions: (1) labeled perikarya and processes are not detected in the rostral forebrain; (2) axonal pathways are intensely labeled whereas most terminal fields are devoid of immunoreactivity.

Original languageEnglish (US)
Pages (from-to)411-422
Number of pages12
JournalJournal of Comparative Neurology
Volume210
Issue number4
DOIs
StatePublished - Jan 1 1982

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Substance P
Central Nervous System
Neurons
Enkephalins
Peripheral Nervous System
Sensory Receptor Cells
Prosencephalon
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "The peroxidase‐antiperoxidase (PAP) technique is used to determine the time of first detection and distribution of neuronal perikarya and processes showing substance P (SP)‐ and enkephalin (EN)‐like immunoreactivity (LI) in the central and peripheral nervous system of the fetal rat. SPLI is first detected in central perikarya at E15. By E18, SPLI is less intensely localized in certain nuclei and shows heavier accumulations of immunoreactivity in central processes in peripheral sensory neurons. ENLI is also widely distributed in perikarya and processes of the central nervous system at E18, but is not detected at E15. The distribution of SPLI and ENLI at E18 is comparable to that previously described in the adult brain with the following exceptions: (1) labeled perikarya and processes are not detected in the rostral forebrain; (2) axonal pathways are intensely labeled whereas most terminal fields are devoid of immunoreactivity.",
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Early prenatal development of substance P and enkephalin‐containing neurons in the rat. / Pickel, Virginia M.; Sumal, Khushdev K.; Miller, Richard J.

In: Journal of Comparative Neurology, Vol. 210, No. 4, 01.01.1982, p. 411-422.

Research output: Contribution to journalArticle

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