Abstract
The peroxidase‐antiperoxidase (PAP) technique is used to determine the time of first detection and distribution of neuronal perikarya and processes showing substance P (SP)‐ and enkephalin (EN)‐like immunoreactivity (LI) in the central and peripheral nervous system of the fetal rat. SPLI is first detected in central perikarya at E15. By E18, SPLI is less intensely localized in certain nuclei and shows heavier accumulations of immunoreactivity in central processes in peripheral sensory neurons. ENLI is also widely distributed in perikarya and processes of the central nervous system at E18, but is not detected at E15. The distribution of SPLI and ENLI at E18 is comparable to that previously described in the adult brain with the following exceptions: (1) labeled perikarya and processes are not detected in the rostral forebrain; (2) axonal pathways are intensely labeled whereas most terminal fields are devoid of immunoreactivity.
Original language | English (US) |
---|---|
Pages (from-to) | 411-422 |
Number of pages | 12 |
Journal | Journal of Comparative Neurology |
Volume | 210 |
Issue number | 4 |
DOIs | |
State | Published - Jan 1 1982 |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
}
Early prenatal development of substance P and enkephalin‐containing neurons in the rat. / Pickel, Virginia M.; Sumal, Khushdev K.; Miller, Richard J.
In: Journal of Comparative Neurology, Vol. 210, No. 4, 01.01.1982, p. 411-422.Research output: Contribution to journal › Article
TY - JOUR
T1 - Early prenatal development of substance P and enkephalin‐containing neurons in the rat
AU - Pickel, Virginia M.
AU - Sumal, Khushdev K.
AU - Miller, Richard J.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - The peroxidase‐antiperoxidase (PAP) technique is used to determine the time of first detection and distribution of neuronal perikarya and processes showing substance P (SP)‐ and enkephalin (EN)‐like immunoreactivity (LI) in the central and peripheral nervous system of the fetal rat. SPLI is first detected in central perikarya at E15. By E18, SPLI is less intensely localized in certain nuclei and shows heavier accumulations of immunoreactivity in central processes in peripheral sensory neurons. ENLI is also widely distributed in perikarya and processes of the central nervous system at E18, but is not detected at E15. The distribution of SPLI and ENLI at E18 is comparable to that previously described in the adult brain with the following exceptions: (1) labeled perikarya and processes are not detected in the rostral forebrain; (2) axonal pathways are intensely labeled whereas most terminal fields are devoid of immunoreactivity.
AB - The peroxidase‐antiperoxidase (PAP) technique is used to determine the time of first detection and distribution of neuronal perikarya and processes showing substance P (SP)‐ and enkephalin (EN)‐like immunoreactivity (LI) in the central and peripheral nervous system of the fetal rat. SPLI is first detected in central perikarya at E15. By E18, SPLI is less intensely localized in certain nuclei and shows heavier accumulations of immunoreactivity in central processes in peripheral sensory neurons. ENLI is also widely distributed in perikarya and processes of the central nervous system at E18, but is not detected at E15. The distribution of SPLI and ENLI at E18 is comparable to that previously described in the adult brain with the following exceptions: (1) labeled perikarya and processes are not detected in the rostral forebrain; (2) axonal pathways are intensely labeled whereas most terminal fields are devoid of immunoreactivity.
UR - http://www.scopus.com/inward/record.url?scp=0019929148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019929148&partnerID=8YFLogxK
U2 - 10.1002/cne.902100407
DO - 10.1002/cne.902100407
M3 - Article
C2 - 6183298
AN - SCOPUS:0019929148
VL - 210
SP - 411
EP - 422
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
SN - 0021-9967
IS - 4
ER -