Early supersensitive changes in [3H]spiroderidol binding in the isolated striatum

John G. Csernansky*, Arnold J. Friedhoff, Kenneth A. Bonnet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Adult mouse striatum was dissected and incubated as an organ culture in chemical medium for up to 24 hours to measure alterations in [3H]spiroperidol binding. High-affinity [3H]spiroperidol binding (ligand concentration 2 nM) was constant throughout the incubation. However, there was a 33% increase in lower-affinity binding (ligand concentration 20 nM) during 24 hours of incubation. Inhibition of dopamine synthesis with alpha-methyl-p-tyrosine methyl ester enhanced the increase in 20 nM [3H]spiroperidol binding by 65%.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Mar 15 1982

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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