Abstract
Adult mouse striatum was dissected and incubated as an organ culture in chemical medium for up to 24 hours to measure alterations in [3H]spiroperidol binding. High-affinity [3H]spiroperidol binding (ligand concentration 2 nM) was constant throughout the incubation. However, there was a 33% increase in lower-affinity binding (ligand concentration 20 nM) during 24 hours of incubation. Inhibition of dopamine synthesis with alpha-methyl-p-tyrosine methyl ester enhanced the increase in 20 nM [3H]spiroperidol binding by 65%.
Original language | English (US) |
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Pages (from-to) | 117-120 |
Number of pages | 4 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 105 |
Issue number | 1 |
DOIs | |
State | Published - Mar 15 1982 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology