Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Sean G. Kelly; Babafemi O. Taiwo; Ying Wu; Ramona Bhatia; Casey S. Kettering; Yi Gao; Suyang Li; Ryan Hutten; Ann B. Ragin

doi:10.1007/s13365-014-0261-7

Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Sean G. Kelly, Babafemi O. Taiwo, Ying Wu, Ramona Bhatia, Casey S. Kettering, Yi Gao, Suyang Li, Ryan Hutten, Ann B. Ragin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.

Original language	English (US)
Pages (from-to)	514-520
Number of pages	7
Journal	Journal of neurovirology
Volume	20
Issue number	5
DOIs	https://doi.org/10.1007/s13365-014-0261-7
State	Published - Oct 21 2014

Keywords

Corpus callosum
Diffusion tensor imaging
Early antiretroviral therapy
Human immunodeficiency virus
Magnetization transfer ratio

ASJC Scopus subject areas

Clinical Neurology
Neurology
Cellular and Molecular Neuroscience
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13365-014-0261-7

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title = "Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum",

abstract = "The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-na{\"i}ve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.",

keywords = "Corpus callosum, Diffusion tensor imaging, Early antiretroviral therapy, Human immunodeficiency virus, Magnetization transfer ratio",

author = "Kelly, {Sean G.} and Taiwo, {Babafemi O.} and Ying Wu and Ramona Bhatia and Kettering, {Casey S.} and Yi Gao and Suyang Li and Ryan Hutten and Ragin, {Ann B.}",

note = "Funding Information: The Chicago Early HIV Infection Study is supported by a grant from the NIH. Publisher Copyright: {\textcopyright} 2014, Journal of NeuroVirology, Inc.",

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AU - Kelly, Sean G.

AU - Taiwo, Babafemi O.

AU - Wu, Ying

AU - Bhatia, Ramona

AU - Kettering, Casey S.

AU - Gao, Yi

AU - Li, Suyang

AU - Hutten, Ryan

AU - Ragin, Ann B.

PY - 2014/10/21

Y1 - 2014/10/21

N2 - The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.

AB - The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.

KW - Corpus callosum

KW - Diffusion tensor imaging

KW - Early antiretroviral therapy

KW - Human immunodeficiency virus

KW - Magnetization transfer ratio

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Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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