TY - JOUR
T1 - Earthworm fibrinolytic enzyme
AU - Zhao, Jing
AU - Qi, Shu Ping
AU - Wu, Jane
AU - Li, Li
AU - He, Rong Qiao
PY - 2005/12/1
Y1 - 2005/12/1
N2 - A group of fibrinolytic enzymes, secreted by the alimentary tract of earthworm such as Lumbricus rubellus and Eisenia fetida, are called earthworm fibrinolytic enzymes (EFEs). They are in characteristics of alkaline trypsin-, chymotrypsin- and elastinase-like serine proteases. These enzymes, having relatively broad substrate specificity, degrade fibrinogen and fibrin directly, and also activate plasminogen (PLg). Their activities can be measured based on the amidolytic activity for several chromogenic substrates, fibrin plate and light scattering of the fibrin turbidity. EFEs have been made as an orally administered fibrinolytic agent. Their current clinical utilizations and some potential new applications will be discussed.
AB - A group of fibrinolytic enzymes, secreted by the alimentary tract of earthworm such as Lumbricus rubellus and Eisenia fetida, are called earthworm fibrinolytic enzymes (EFEs). They are in characteristics of alkaline trypsin-, chymotrypsin- and elastinase-like serine proteases. These enzymes, having relatively broad substrate specificity, degrade fibrinogen and fibrin directly, and also activate plasminogen (PLg). Their activities can be measured based on the amidolytic activity for several chromogenic substrates, fibrin plate and light scattering of the fibrin turbidity. EFEs have been made as an orally administered fibrinolytic agent. Their current clinical utilizations and some potential new applications will be discussed.
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U2 - 10.1016/S1572-5995(05)80048-1
DO - 10.1016/S1572-5995(05)80048-1
M3 - Article
AN - SCOPUS:77957766944
SN - 1572-5995
VL - 30
SP - 825
EP - 847
JO - Studies in Natural Products Chemistry
JF - Studies in Natural Products Chemistry
IS - C
ER -