ebi regulates epidermal growth factor receptor signaling pathways in Drosophila

Xinzhong Dong, Leo Tsuda, Kenton H. Zavitz, Michael Lin, Songhui Li, Richard W. Carthew, S. Lawrence Zipursky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


ebi regulates the epidermal growth factor receptor (EGFR) signaling pathway at multiple steps in Drosophila development. Mutations in ebi and Egfr lead to similar phenotypes and show genetic interactions. However, ebi does not show genetic interactions with other RTKs (e.g., torso) or with components of the canonical Ras/MAP kinase pathway, ebi encodes an evolutionarily conserved protein with a unique amino terminus, distantly related to F-box sequences, and six tandemly arranged carboxy-terminal WD40 repeats. The existence of closely related proteins in yeast, plants, and humans suggests that ebi functions in a highly conserved biochemical pathway. Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development.

Original languageEnglish (US)
Pages (from-to)954-965
Number of pages12
JournalGenes and Development
Issue number8
StatePublished - Apr 15 1999


  • EGFR
  • Ebi
  • F box
  • Protein degradation
  • Tramtrack88
  • WD40 repeats

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'ebi regulates epidermal growth factor receptor signaling pathways in Drosophila'. Together they form a unique fingerprint.

Cite this