Eccrine Syringofibroadenoma in Association with Acquired Epidermodysplasia Verruciformis

Timothy Tan, Joan Guitart, Luzheng Lisa Liu, Joaquin C. Brieva, Sapna Amin, Monica Rani, Pedram Gerami, Pedram Yazdan*

*Corresponding author for this work

Research output: Contribution to journalArticle


A 75-year-old man with human immunodeficiency virus infection and numerous biopsy-proven warts for 10 years, refractory to cryosurgery, cimetidine, and topical imiquimod, presented with numerous pink to hypopigmented verrucous papules and plaques involving the face, trunk, buttocks, and groin. Laboratory evaluation revealed a CD4 T-cell count of 62 cells per microliter and human immunodeficiency virus viral load of <117 copies per milliliter. Biopsy of a plaque groin lesion was performed. Histopathology revealed vertically oriented anastomosing strands of basaloid epithelium arising from multiple points along the epidermis in a background fibrovascular stroma. Ductal differentiation was identified. Areas of epidermis showed compact orthokeratosis, coarse hypergranulosis, and keratinocytes with abundant steel-blue-gray cytoplasm, indicative of viral cytopathic changes. Cytologic atypia was not identified. Human papillomavirus (HPV) genotyping of this lesion was positive for types 5 and 14. Overall, the findings were consistent with epidermodysplasia verruciformis in association with eccrine syringofibroadenoma (ESFA). The patient was subsequently treated with acitretin and showed clinical improvement. ESFA is an uncommon benign adnexal tumor with unknown pathogenesis. Although its association with HPV has rarely been reported, ESFA in the setting of acquired epidermodysplasia verruciformis has not been described. The development of ESFA in this case may be the result of HPV-induced cellular transformation.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number7
StatePublished - Jul 1 2017


  • eccrine syringofibroadenoma
  • epidermodysplasia verruciformis
  • human papillomavirus
  • immunodeficiency

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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