Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape

Zoran B. Popović; Giuseppe Saracino; Dimitri Deserranno; Hua Yang; Neil L. Greenberg; Masami Takagaki; Kiyotaka Fukamachi; Yoshie Ochiai; Masahiro Inoue; Soren Schenk; Kazuyoshi Doi; Jianxin Qin; Patrick M. McCarthy; Takahiro Shiota; James D. Thomas

doi:10.1016/j.echo.2004.01.015

Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape

Zoran B. Popović, Giuseppe Saracino, Dimitri Deserranno, Hua Yang, Neil L. Greenberg, Masami Takagaki, Kiyotaka Fukamachi, Yoshie Ochiai, Masahiro Inoue, Soren Schenk, Kazuyoshi Doi, Jianxin Qin, Patrick M. McCarthy, Takahiro Shiota, James D. Thomas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.

Original language	English (US)
Pages (from-to)	411-417
Number of pages	7
Journal	Journal of the American Society of Echocardiography
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.echo.2004.01.015
State	Published - May 1 2004

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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Popović, Z. B., Saracino, G., Deserranno, D., Yang, H., Greenberg, N. L., Takagaki, M., Fukamachi, K., Ochiai, Y., Inoue, M., Schenk, S., Doi, K., Qin, J., McCarthy, P. M., Shiota, T., & Thomas, J. D. (2004). Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape. Journal of the American Society of Echocardiography, 17(5), 411-417. https://doi.org/10.1016/j.echo.2004.01.015

Popović, Zoran B. ; Saracino, Giuseppe ; Deserranno, Dimitri ; Yang, Hua ; Greenberg, Neil L. ; Takagaki, Masami ; Fukamachi, Kiyotaka ; Ochiai, Yoshie ; Inoue, Masahiro ; Schenk, Soren ; Doi, Kazuyoshi ; Qin, Jianxin ; McCarthy, Patrick M. ; Shiota, Takahiro ; Thomas, James D. / Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape. In: Journal of the American Society of Echocardiography. 2004 ; Vol. 17, No. 5. pp. 411-417.

@article{028a4eb91cd24f3788aa8621ef3abf2e,

title = "Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape",

abstract = "We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.",

author = "Popovi{\'c}, {Zoran B.} and Giuseppe Saracino and Dimitri Deserranno and Hua Yang and Greenberg, {Neil L.} and Masami Takagaki and Kiyotaka Fukamachi and Yoshie Ochiai and Masahiro Inoue and Soren Schenk and Kazuyoshi Doi and Jianxin Qin and McCarthy, {Patrick M.} and Takahiro Shiota and Thomas, {James D.}",

year = "2004",

month = may,

day = "1",

doi = "10.1016/j.echo.2004.01.015",

language = "English (US)",

volume = "17",

pages = "411--417",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

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Popović, ZB, Saracino, G, Deserranno, D, Yang, H, Greenberg, NL, Takagaki, M, Fukamachi, K, Ochiai, Y, Inoue, M, Schenk, S, Doi, K, Qin, J, McCarthy, PM, Shiota, T & Thomas, JD 2004, 'Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape', Journal of the American Society of Echocardiography, vol. 17, no. 5, pp. 411-417. https://doi.org/10.1016/j.echo.2004.01.015

Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape. / Popović, Zoran B.; Saracino, Giuseppe; Deserranno, Dimitri; Yang, Hua; Greenberg, Neil L.; Takagaki, Masami; Fukamachi, Kiyotaka; Ochiai, Yoshie; Inoue, Masahiro; Schenk, Soren; Doi, Kazuyoshi; Qin, Jianxin; McCarthy, Patrick M.; Shiota, Takahiro; Thomas, James D.

In: Journal of the American Society of Echocardiography, Vol. 17, No. 5, 01.05.2004, p. 411-417.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape

AU - Popović, Zoran B.

AU - Saracino, Giuseppe

AU - Deserranno, Dimitri

AU - Yang, Hua

AU - Greenberg, Neil L.

AU - Takagaki, Masami

AU - Fukamachi, Kiyotaka

AU - Ochiai, Yoshie

AU - Inoue, Masahiro

AU - Schenk, Soren

AU - Doi, Kazuyoshi

AU - Qin, Jianxin

AU - McCarthy, Patrick M.

AU - Shiota, Takahiro

AU - Thomas, James D.

PY - 2004/5/1

Y1 - 2004/5/1

N2 - We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.

AB - We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.

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