TY - JOUR
T1 - Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape
AU - Popović, Zoran B.
AU - Saracino, Giuseppe
AU - Deserranno, Dimitri
AU - Yang, Hua
AU - Greenberg, Neil L.
AU - Takagaki, Masami
AU - Fukamachi, Kiyotaka
AU - Ochiai, Yoshie
AU - Inoue, Masahiro
AU - Schenk, Soren
AU - Doi, Kazuyoshi
AU - Qin, Jianxin
AU - McCarthy, Patrick M.
AU - Shiota, Takahiro
AU - Thomas, James D.
N1 - Funding Information:
Supported in part by Myocor Inc (Maple Grove, Minnesota). Dr McCarthy is a consultant to Myocor Inc.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/5
Y1 - 2004/5
N2 - We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.
AB - We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.
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U2 - 10.1016/j.echo.2004.01.015
DO - 10.1016/j.echo.2004.01.015
M3 - Article
C2 - 15122179
AN - SCOPUS:3042770633
VL - 17
SP - 411
EP - 417
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 5
ER -