Echocardiographic assessment of regional ventricular function after device-based change of left ventricular shape

Zoran B. Popović, Giuseppe Saracino, Dimitri Deserranno, Hua Yang, Neil L. Greenberg, Masami Takagaki, Kiyotaka Fukamachi, Yoshie Ochiai, Masahiro Inoue, Soren Schenk, Kazuyoshi Doi, Jianxin Qin, Patrick M. McCarthy, Takahiro Shiota, James D. Thomas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We assessed the effects of implantation of Myosplint (Myocor, Maple Grove, Minn), a device that changes left ventricular (LV) cross-sectional shape from circular to bilobar, on regional LV function. A total of 10 open-chest dogs with tachycardia-induced cardiomyopathy were studied before and after Myosplint implantation. LV cross-sectional epicardial echocardiography at the papillary muscle level was performed along with acquisition of hemodynamic data. LV normalized thickening, fractional thickening, end-diastolic thickness, and end-diastolic curvatures were calculated for 10 LV segments. Myosplint implantation did not affect LV hemodynamics, but decreased average end-diastolic curvature (P < .0001) and increased its segmental heterogeneity (P < .0001). There was no change in average fractional thickening, whereas normalized thickening increased (P = .05). In contrast, segmental heterogeneity of both normalized and fractional thickening increased (P = .02 and P = .01, respectively). Structural modeling confirmed that Myosplint implantation increases regional stress heterogeneity and curvature heterogeneity. LV cross-sectional shape markedly affects regional LV performance.

Original languageEnglish (US)
Pages (from-to)411-417
Number of pages7
JournalJournal of the American Society of Echocardiography
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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