ECLS for preemies: The artificial placenta

Benjamin S. Bryner, George B. Mychaliska*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The high mortality and morbidity associated with respiratory failure among extremely low gestational age newborns (ELGANs) remains an unsolved problem. A logical strategy to avoid these complications would involve re-creating the intrauterine environment with extracorporeal membrane oxygenation (ECMO) instead of mechanical ventilation. Such a device, termed an artificial placenta, was first researched over 50 years ago. AP models vary, but all incorporate ECMO involving the umbilical vessels, lack of mechanical ventilation, and low partial pressure of oxygen to preserve fetal circulation. Current research has focused on low-volume pumpless arteriovenous circuits as well as pump-driven venovenous circuits.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalSeminars in Perinatology
Issue number2
StatePublished - Mar 2014


  • Artificial placenta
  • ECLS
  • ECMO
  • Extracorporeal life support
  • Extracorporeal membrane oxygenation
  • Respiratory failure

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health


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