Ectopic ACTH and CRH Co-secreting tumor localized by 68Ga-DOTA-TATE PET/CT

Georgios Z. Papadakis, Ulas Bagci, Samira M. Sadowski, Nicholas J. Patronas, Constantine A. Stratakis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Diagnosis of ectopic adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) co-secreting tumors causing Cushing syndrome (CS) is challenging because these tumors are rare and their diagnosis is frequently confused with Cushing disease (CD), caused by the effect of CRH on the pituitary. We report a case of a 21-year-old male patient who was referred to our institution with persistent hypercortisolemia and CS after undergoing unnecessary transsphenoidal surgery (TSS). 68Ga-DOTA-TATE PET/CT revealed increased tracer uptake in the thymus, which was histologically proven to be a neuroendocrine tumor (NET) that stained positive for ACTH and CRH. Imaging with 18F-FDG PET/CT was not diagnostic.

Original languageEnglish (US)
Pages (from-to)576-578
Number of pages3
JournalClinical nuclear medicine
Issue number7
StatePublished - Jul 20 2015
Externally publishedYes


  • Cushing syndrome
  • ectopic ACTH/CRH co-secreting tumors
  • thymus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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