Ectopic expression of retrotransposon-derived peg11/rtl1 contributes to the callipyge muscular hypertrophy

Xuewen Xu, Fabien Ectors, Erica Ellen Davis, Dimitri Pirottin, Huijun Cheng, Frédéric Farnir, Tracy Hadfield, Noelle Cockett, Carole Charlier, Michel Georges, Haruko Takeda

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/ Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep.

Original languageEnglish (US)
Article numbere0140594
JournalPloS one
Issue number10
StatePublished - Oct 16 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General


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