Ectopic Fat Depots And Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups

Sachin K. Garg, Feng Lin, Namratha R Kandula, Jingzhong Ding, Jeffrey Carr, Matthew Allison, Kiang Liu, David Herrington, Dhananjay Vaidya, Eric Vittinghoff, Alka M. Kanaya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background-South Asians have a low body mass index and high prevalence of cardiovascular disease (CVD) relative to other racial/ethnic groups. Radiographically detected ectopic fat distribution is better associated with CVD than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence/severity of coronary artery calcium (CAC), a predictor of incident CVD events, among South Asians compared with other racial/ethnic groups. Methods and Results-We examined the associations of radiographically detected visceral, intermuscular, intrahepatic, and pericardial fat with CAC among adults without baseline CVD. We compared 803 South Asians in the Mediators of Atherosclerosis in South Asians Living in America to 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis: 2622 whites, 1893 blacks, 1496 Latinos, and 803 Chinese Americans. We adjusted for body mass index and known CVD risk factors. South Asians had the highest intrahepatic fat and lowest pericardial fat volume (PFV). There was a positive graded association between ectopic fat and higher CAC scores in all the groups with the strongest associations observed with PFV. PFV was independently associated with CAC severity in South Asians (P=0.01) and blacks (P=0.05) and borderline in whites (P=0.06). PFV partially explained the higher CAC burden in South Asians compared with blacks, but not the other racial/ethnic groups. Conclusions-Differences in PFV explain a small fraction of the higher CAC burden in South Asians. Our findings suggest that ectopic fat depots may not explain the elevated CAC risk in South Asians.

Original languageEnglish (US)
Article numbere004257
JournalJournal of the American Heart Association
Volume5
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Ethnic Groups
Coronary Vessels
Fats
Calcium
Cardiovascular Diseases
Body Mass Index
Atherosclerosis
Asian Americans
Hispanic Americans

Keywords

  • Adipose tissue
  • Coronary artery calcification
  • Ethnicity
  • MESA (Multi-Ethnic Study of Atherosclerosis)
  • Pericardial fat
  • South Asian

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Garg, Sachin K. ; Lin, Feng ; Kandula, Namratha R ; Ding, Jingzhong ; Carr, Jeffrey ; Allison, Matthew ; Liu, Kiang ; Herrington, David ; Vaidya, Dhananjay ; Vittinghoff, Eric ; Kanaya, Alka M. / Ectopic Fat Depots And Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups. In: Journal of the American Heart Association. 2016 ; Vol. 5, No. 11.
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abstract = "Background-South Asians have a low body mass index and high prevalence of cardiovascular disease (CVD) relative to other racial/ethnic groups. Radiographically detected ectopic fat distribution is better associated with CVD than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence/severity of coronary artery calcium (CAC), a predictor of incident CVD events, among South Asians compared with other racial/ethnic groups. Methods and Results-We examined the associations of radiographically detected visceral, intermuscular, intrahepatic, and pericardial fat with CAC among adults without baseline CVD. We compared 803 South Asians in the Mediators of Atherosclerosis in South Asians Living in America to 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis: 2622 whites, 1893 blacks, 1496 Latinos, and 803 Chinese Americans. We adjusted for body mass index and known CVD risk factors. South Asians had the highest intrahepatic fat and lowest pericardial fat volume (PFV). There was a positive graded association between ectopic fat and higher CAC scores in all the groups with the strongest associations observed with PFV. PFV was independently associated with CAC severity in South Asians (P=0.01) and blacks (P=0.05) and borderline in whites (P=0.06). PFV partially explained the higher CAC burden in South Asians compared with blacks, but not the other racial/ethnic groups. Conclusions-Differences in PFV explain a small fraction of the higher CAC burden in South Asians. Our findings suggest that ectopic fat depots may not explain the elevated CAC risk in South Asians.",
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author = "Garg, {Sachin K.} and Feng Lin and Kandula, {Namratha R} and Jingzhong Ding and Jeffrey Carr and Matthew Allison and Kiang Liu and David Herrington and Dhananjay Vaidya and Eric Vittinghoff and Kanaya, {Alka M.}",
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Garg, SK, Lin, F, Kandula, NR, Ding, J, Carr, J, Allison, M, Liu, K, Herrington, D, Vaidya, D, Vittinghoff, E & Kanaya, AM 2016, 'Ectopic Fat Depots And Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups', Journal of the American Heart Association, vol. 5, no. 11, e004257. https://doi.org/10.1161/JAHA.116.004257

Ectopic Fat Depots And Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups. / Garg, Sachin K.; Lin, Feng; Kandula, Namratha R; Ding, Jingzhong; Carr, Jeffrey; Allison, Matthew; Liu, Kiang; Herrington, David; Vaidya, Dhananjay; Vittinghoff, Eric; Kanaya, Alka M.

In: Journal of the American Heart Association, Vol. 5, No. 11, e004257, 01.11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ectopic Fat Depots And Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups

AU - Garg, Sachin K.

AU - Lin, Feng

AU - Kandula, Namratha R

AU - Ding, Jingzhong

AU - Carr, Jeffrey

AU - Allison, Matthew

AU - Liu, Kiang

AU - Herrington, David

AU - Vaidya, Dhananjay

AU - Vittinghoff, Eric

AU - Kanaya, Alka M.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background-South Asians have a low body mass index and high prevalence of cardiovascular disease (CVD) relative to other racial/ethnic groups. Radiographically detected ectopic fat distribution is better associated with CVD than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence/severity of coronary artery calcium (CAC), a predictor of incident CVD events, among South Asians compared with other racial/ethnic groups. Methods and Results-We examined the associations of radiographically detected visceral, intermuscular, intrahepatic, and pericardial fat with CAC among adults without baseline CVD. We compared 803 South Asians in the Mediators of Atherosclerosis in South Asians Living in America to 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis: 2622 whites, 1893 blacks, 1496 Latinos, and 803 Chinese Americans. We adjusted for body mass index and known CVD risk factors. South Asians had the highest intrahepatic fat and lowest pericardial fat volume (PFV). There was a positive graded association between ectopic fat and higher CAC scores in all the groups with the strongest associations observed with PFV. PFV was independently associated with CAC severity in South Asians (P=0.01) and blacks (P=0.05) and borderline in whites (P=0.06). PFV partially explained the higher CAC burden in South Asians compared with blacks, but not the other racial/ethnic groups. Conclusions-Differences in PFV explain a small fraction of the higher CAC burden in South Asians. Our findings suggest that ectopic fat depots may not explain the elevated CAC risk in South Asians.

AB - Background-South Asians have a low body mass index and high prevalence of cardiovascular disease (CVD) relative to other racial/ethnic groups. Radiographically detected ectopic fat distribution is better associated with CVD than body mass index. We assessed whether differences in ectopic fat depots explained differences in the prevalence/severity of coronary artery calcium (CAC), a predictor of incident CVD events, among South Asians compared with other racial/ethnic groups. Methods and Results-We examined the associations of radiographically detected visceral, intermuscular, intrahepatic, and pericardial fat with CAC among adults without baseline CVD. We compared 803 South Asians in the Mediators of Atherosclerosis in South Asians Living in America to 4 racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis: 2622 whites, 1893 blacks, 1496 Latinos, and 803 Chinese Americans. We adjusted for body mass index and known CVD risk factors. South Asians had the highest intrahepatic fat and lowest pericardial fat volume (PFV). There was a positive graded association between ectopic fat and higher CAC scores in all the groups with the strongest associations observed with PFV. PFV was independently associated with CAC severity in South Asians (P=0.01) and blacks (P=0.05) and borderline in whites (P=0.06). PFV partially explained the higher CAC burden in South Asians compared with blacks, but not the other racial/ethnic groups. Conclusions-Differences in PFV explain a small fraction of the higher CAC burden in South Asians. Our findings suggest that ectopic fat depots may not explain the elevated CAC risk in South Asians.

KW - Adipose tissue

KW - Coronary artery calcification

KW - Ethnicity

KW - MESA (Multi-Ethnic Study of Atherosclerosis)

KW - Pericardial fat

KW - South Asian

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U2 - 10.1161/JAHA.116.004257

DO - 10.1161/JAHA.116.004257

M3 - Article

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