TY - JOUR
T1 - Eczema Is Associated with Childhood Speech Disorder
T2 - A Retrospective Analysis from the National Survey of Children's Health and the National Health Interview Survey
AU - Strom, Mark A.
AU - Silverberg, Jonathan I.
N1 - Funding Information:
Supported by the Agency for Healthcare Research and Quality (K12HS023011) and the Dermatology Foundation.
Funding Information:
Supported by the Agency for Healthcare Research and Quality ( K12HS023011 ) and the Dermatology Foundation . The authors declare no conflicts of interest.
Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objective To determine if eczema is associated with an increased risk of a speech disorder. Study design We analyzed data on 354 416 children and adolescents from 19 US population-based cohorts: the 2003-2004 and 2007-2008 National Survey of Children's Health and 1997-2013 National Health Interview Survey, each prospective, questionnaire-based cohorts. Results In multivariate survey logistic regression models adjusting for sociodemographics and comorbid allergic disease, eczema was significantly associated with higher odds of speech disorder in 12 of 19 cohorts (P <.05). The pooled prevalence of speech disorder in children with eczema was 4.7% (95% CI 4.5%-5.0%) compared with 2.2% (95% CI 2.2%-2.3%) in children without eczema. In pooled multivariate analysis, eczema was associated with increased odds of speech disorder (aOR [95% CI] 1.81 [1.57-2.05], P <.001). In a single study assessing eczema severity, mild (1.36 [1.02-1.81], P =.03) and severe eczema (3.56 [1.70-7.48], P <.001) were associated with higher odds of speech disorder. History of eczema was associated with moderate (2.35 [1.34-4.10], P =.003) and severe (2.28 [1.11-4.72], P =.03) speech disorder. Finally, significant interactions were found, such that children with both eczema and attention deficit disorder with or without hyperactivity or sleep disturbance had vastly increased risk of speech disorders than either by itself. Conclusions Pediatric eczema may be associated with increased risk of speech disorder. Further, prospective studies are needed to characterize the exact nature of this association.
AB - Objective To determine if eczema is associated with an increased risk of a speech disorder. Study design We analyzed data on 354 416 children and adolescents from 19 US population-based cohorts: the 2003-2004 and 2007-2008 National Survey of Children's Health and 1997-2013 National Health Interview Survey, each prospective, questionnaire-based cohorts. Results In multivariate survey logistic regression models adjusting for sociodemographics and comorbid allergic disease, eczema was significantly associated with higher odds of speech disorder in 12 of 19 cohorts (P <.05). The pooled prevalence of speech disorder in children with eczema was 4.7% (95% CI 4.5%-5.0%) compared with 2.2% (95% CI 2.2%-2.3%) in children without eczema. In pooled multivariate analysis, eczema was associated with increased odds of speech disorder (aOR [95% CI] 1.81 [1.57-2.05], P <.001). In a single study assessing eczema severity, mild (1.36 [1.02-1.81], P =.03) and severe eczema (3.56 [1.70-7.48], P <.001) were associated with higher odds of speech disorder. History of eczema was associated with moderate (2.35 [1.34-4.10], P =.003) and severe (2.28 [1.11-4.72], P =.03) speech disorder. Finally, significant interactions were found, such that children with both eczema and attention deficit disorder with or without hyperactivity or sleep disturbance had vastly increased risk of speech disorders than either by itself. Conclusions Pediatric eczema may be associated with increased risk of speech disorder. Further, prospective studies are needed to characterize the exact nature of this association.
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U2 - 10.1016/j.jpeds.2015.09.066
DO - 10.1016/j.jpeds.2015.09.066
M3 - Article
C2 - 26520915
AN - SCOPUS:84955625135
SN - 0022-3476
VL - 168
SP - 185-192.e4
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -