Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus

Neuroscience

• Alzheimer's Disease 100%
• Amyloid Protein 50%
• Axon 50%
• Cell Adhesion Proteins 50%
• Dentate Gyrus 50%
• Disorientation 50%
• Germ Cell 100%
• Granule Cell 50%
• Hippocampus 100%
• Mouse Brain 50%
• Nervous System Cell 50%
• Proteolytic Processing 50%
• Tamoxifen 50%

Keyphrases

• Adult Mouse Brain 7%
• Alzheimer's Disease 14%
• Amyloid Plaques 7%
• Axon 7%
• Axonal Guidance 7%
• Axonal Pathways 7%
• BACE1 Inhibition 21%
• BACE1 Inhibitor 100%
• Cell Adhesion Proteins 7%
• CHL1 7%
• Clinical Trials 100%
• Dentate Granule Cells 7%
• Disorganization 7%
• Embryonic Development 7%
• Germ Cells 14%
• Hippocampal Mossy Fibers 7%
• Hippocampus 100%
• Infrapyramidal 14%
• Inhibitor Drug 7%
• Knock-in Mouse Model 100%
• Neurological Phenotype 7%
• Neuronal Cells 7%
• Postnatal Development 7%
• Proteolytic Processing 7%
• Rate-limiting Enzyme 7%
• Reduced Length 7%
• Small Molecule Inhibitors 7%
• Tamoxifen Inducible 7%
• Whole-body 7%
• β-site APP-cleaving Enzyme 1 (BACE1) 100%

Biochemistry, Genetics and Molecular Biology

• Amyloid Protein 25%
• Axon 25%
• Cell Adhesion Proteins 25%
• CHL1 25%
• Clinical Trial 100%
• Embryogenesis 25%
• Enzyme 25%
• Germ Cell 50%
• Germline 50%
• Granule Cell 25%
• Knockout Mouse 100%
• Postnatal Development 25%
• Proteolytic Processing 25%
• Small Molecule 25%