Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders

John T. Metz; Henry H. Holcomb; Herbert Y. Meltzer

doi:10.1016/0006-3223(88)90007-8

Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders

John T. Metz^*, Henry H. Holcomb, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effect of the serotonin precursor dl-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.

Original language	English (US)
Pages (from-to)	602-611
Number of pages	10
Journal	Biological psychiatry
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/0006-3223(88)90007-8
State	Published - Mar 15 1988

ASJC Scopus subject areas

Biological Psychiatry

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abstract = "The effect of the serotonin precursor dl-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.",

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AU - Metz, John T.

AU - Holcomb, Henry H.

AU - Meltzer, Herbert Y.

PY - 1988/3/15

Y1 - 1988/3/15

N2 - The effect of the serotonin precursor dl-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.

AB - The effect of the serotonin precursor dl-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.

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Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders

Abstract

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