Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders

John T. Metz*, Henry H. Holcomb, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effect of the serotonin precursor dl-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.

Original languageEnglish (US)
Pages (from-to)602-611
Number of pages10
JournalBiological psychiatry
Volume23
Issue number6
DOIs
StatePublished - Mar 15 1988

ASJC Scopus subject areas

  • Biological Psychiatry

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