Effect of 6-aminonicotinamide on monoamine oxidase and Na+K+ATPase activity in different regions of rat brain

Chandrashekhar K. Mayanil, Syed M I Kazmi, Najma Z. Baquer*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The monoamine oxidase activity in the cerebral hemispheres decreased significantly after 2, 4, 8 and 16 hr of 6-amino-nicotinamide (35 mg/kg body weight, i.p.) administration. In the cerebellum, the MAO activity was not affected significantly. In the brain stem, however, a significant increase was observed after 2 hr of drug administration followed by a gradual decrease at later time intervals. The Na+K+ATPase activity in the cerebral hemispheres was increased significantly at 2 and 4 hr of 6-aminonicotinamide administration. This was followed by a gradual decrease at later time intervals. In the cerebellum, like monoamine oxidase, the Na+K+ATPase did not change significantly. The brain stem showed a decrease at 2 hr of drug administration, followed by a significant increase at 4 hr and then a gradual decrease to near control values.

Original languageEnglish (US)
Pages (from-to)3021-3023
Number of pages3
JournalBiochemical Pharmacology
Volume33
Issue number19
DOIs
StatePublished - Oct 1 1984

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ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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