Effect of 6-methoxy-tetrahydro-β-carboline on serum prolactin levels of male rats

V. S. Fang, B. T. Ho, H. Y. Meltzer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

6-Methoxy-tetrahydro-β-carboline (MTBC) is a sterically hindered analog of serotonin which may be produced endogenously. MTBC stimulated rat prolactin release in a dose-related manner. The onset of the hyperprolactinemic effect was rapid (peak around 15 min) and of short duration (<60 min). Its effect upon serum prolactin was blocked by methysergide, a serotonin receptor blocker, and was potentiated by pretreatment with parachlorophenylalanine, an inhibitor of serotonin synthesis, suggesting its action could be the result of a direct serotonergic effect on the brain.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalCommunications in Psychopharmacology
Volume2
Issue number1
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Medicine(all)

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