Abstract
6-Methoxy-tetrahydro-β-carboline (MTBC) is a sterically hindered analog of serotonin which may be produced endogenously. MTBC stimulated rat prolactin release in a dose-related manner. The onset of the hyperprolactinemic effect was rapid (peak around 15 min) and of short duration (<60 min). Its effect upon serum prolactin was blocked by methysergide, a serotonin receptor blocker, and was potentiated by pretreatment with parachlorophenylalanine, an inhibitor of serotonin synthesis, suggesting its action could be the result of a direct serotonergic effect on the brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | Communications In Psychopharmacology |
| Volume | 2 |
| Issue number | 1 |
| State | Published - 1978 |
ASJC Scopus subject areas
- General Medicine