Effect of administered 20 β-hydroxysteroid dehydrogenase on serum progesterone in the rat

Robert T. Chatterton*, Janet Chien

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Administration of 20 β-hydroxysteroid dehydrogenase from Streptomyces hydrogenans to rats either intravenously or intraperitoneally results in decreases in serum progesterone. Detectable quantities of the enzyme were present in serum 2 days after intravenous injection. Intraperitoneal injections of 1.3 to 1.9 units of enzyme were effective in reducing serum progesterone over a longer period of time than the corresponding i.v. injections despite the failure of the enzyme to be absorbed into blood in detectable amounts; the serum concentration 2 hours after injection was 23% of that present before injection. The response was similar in diestrous and proestrous rats.

Original languageEnglish (US)
Pages (from-to)485-492
Number of pages8
JournalSteroids
Volume22
Issue number4
DOIs
StatePublished - Oct 1973

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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