Effect of adrenalectomy and corticosterone on [3H]imipramine binding in rat blood platelets and brain

Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0014-2999(86)90717-X

Effect of adrenalectomy and corticosterone on [³H]imipramine binding in rat blood platelets and brain

Ramesh C. Arora^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The effect of adrenalectomy and administration of glucocorticoids on [³H]imipramine binding (IB) of rat blood platelets and brain was investigated. Adrenalectomy significantly increased both K_d and B_max of IB in the blood platelets but not the brain of male Sprague-Dawley rats. Administration of corticosterone acetate, 1 mg/kg i.p. for 7 days, decreased both K_d and B_max in the blood platelets of sham-operated rats, but only B_max in adrenalectomized rats. Corticosterone administration also decreased B_max in frontal cortex and hypothalamus of sham and adrenalectomized rats but had no effect on K_d. These results suggest that glucocorticoids may modulate imipramine binding.

Original language	English (US)
Pages (from-to)	415-419
Number of pages	5
Journal	European Journal of Pharmacology
Volume	123
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(86)90717-X
State	Published - Apr 29 1986

Funding

The research reported was supported, in parts by USPH MH 30,059 and by Illinois Department of Mental Health. Herbert Y. Meltzer is recipient of USPHS Research Career Scientist award 47,808.

Keywords

Adrenalectomy
B
Corticosterone
Imipramine binding
K

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(86)90717-X

Cite this

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title = "Effect of adrenalectomy and corticosterone on [3H]imipramine binding in rat blood platelets and brain",

abstract = "The effect of adrenalectomy and administration of glucocorticoids on [3H]imipramine binding (IB) of rat blood platelets and brain was investigated. Adrenalectomy significantly increased both Kd and Bmax of IB in the blood platelets but not the brain of male Sprague-Dawley rats. Administration of corticosterone acetate, 1 mg/kg i.p. for 7 days, decreased both Kd and Bmax in the blood platelets of sham-operated rats, but only Bmax in adrenalectomized rats. Corticosterone administration also decreased Bmax in frontal cortex and hypothalamus of sham and adrenalectomized rats but had no effect on Kd. These results suggest that glucocorticoids may modulate imipramine binding.",

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note = "Funding Information: The research reported was supported, in parts by USPH MH 30,059 and by Illinois Department of Mental Health. Herbert Y. Meltzer is recipient of USPHS Research Career Scientist award 47,808.",

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N2 - The effect of adrenalectomy and administration of glucocorticoids on [3H]imipramine binding (IB) of rat blood platelets and brain was investigated. Adrenalectomy significantly increased both Kd and Bmax of IB in the blood platelets but not the brain of male Sprague-Dawley rats. Administration of corticosterone acetate, 1 mg/kg i.p. for 7 days, decreased both Kd and Bmax in the blood platelets of sham-operated rats, but only Bmax in adrenalectomized rats. Corticosterone administration also decreased Bmax in frontal cortex and hypothalamus of sham and adrenalectomized rats but had no effect on Kd. These results suggest that glucocorticoids may modulate imipramine binding.

AB - The effect of adrenalectomy and administration of glucocorticoids on [3H]imipramine binding (IB) of rat blood platelets and brain was investigated. Adrenalectomy significantly increased both Kd and Bmax of IB in the blood platelets but not the brain of male Sprague-Dawley rats. Administration of corticosterone acetate, 1 mg/kg i.p. for 7 days, decreased both Kd and Bmax in the blood platelets of sham-operated rats, but only Bmax in adrenalectomized rats. Corticosterone administration also decreased Bmax in frontal cortex and hypothalamus of sham and adrenalectomized rats but had no effect on Kd. These results suggest that glucocorticoids may modulate imipramine binding.

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