Effect of adrenalectomy and corticosterone on [3H]imipramine binding in rat blood platelets and brain

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The effect of adrenalectomy and administration of glucocorticoids on [3H]imipramine binding (IB) of rat blood platelets and brain was investigated. Adrenalectomy significantly increased both Kd and Bmax of IB in the blood platelets but not the brain of male Sprague-Dawley rats. Administration of corticosterone acetate, 1 mg/kg i.p. for 7 days, decreased both Kd and Bmax in the blood platelets of sham-operated rats, but only Bmax in adrenalectomized rats. Corticosterone administration also decreased Bmax in frontal cortex and hypothalamus of sham and adrenalectomized rats but had no effect on Kd. These results suggest that glucocorticoids may modulate imipramine binding.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalEuropean Journal of Pharmacology
Volume123
Issue number3
DOIs
StatePublished - Apr 29 1986

Keywords

  • Adrenalectomy
  • B
  • Corticosterone
  • Imipramine binding
  • K

ASJC Scopus subject areas

  • Pharmacology

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