Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: Validation of contemporary guidelines

Daniel Rinewalt, Patrick M. McCarthy*, Sukit Chris Malaisrie, Paul W.M. Fedak, Adin Cristian Andrei, Jyothy J. Puthumana, Robert O. Bonow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Results Of the 456 patients, 250 (55%) underwent AVR and 206 (45%) AVR/AN, with 98% compliance with the current guidelines. The overall 30-day mortality was 0.9%. The AVR AD < 45-mm group had adjusted short- and medium-term survival similar to that of the AVR/AN AD 45- to 49-mm and AVR/AN AD 50-mm groups, with a 30-day mortality of 0.8%, 0%, and 1.9%, respectively (P =.41). The propensity score-matched AVR/AN AD 50-mm group had significantly greater rates of reintubation than either the AVR AD < 45-mm (P =.012) or AVR/AN AD 45- to 49-mm (P =.04) group and greater rates of prolonged ventilation (P =.022) than the AVR AD < 45-mm group. No significant differences were found in reoperation or myocardial infarction among the subgroups.

Conclusions In patients with undergoing AVR, no increase was seen in morbidity or mortality when adding aortic replacement with an AD of 45 to 49 mm, in accordance with the 2006 ACC/AHA guidelines, although the AVR/AN AD 50-mm group had a greater risk of respiratory complications. Our findings indicate that compliance with the ACC/AHA guidelines is safe in select centers.

Objective Bicuspid aortic valve (BAV) disease is associated with aortic dilatation and aneurysm (AN) formation. The American College of Cardiology/American Heart Association (ACC/AHA) 2006 guidelines recommend replacement of the ascending aorta for an aortic diameter (AD) > 45 mm in patients undergoing aortic valve replacement (AVR). We evaluated the outcomes of AVR and AVR with aortic replacement (AVR/AN).

Methods We retrospectively reviewed (2004-2011) the data from 456 patients with BAV and compared the morbidity and mortality between the AVR and AVR/AN groups and 3 subgroups: AVR with an AD < 45 mm; AVR/AN with an AD of 45 to 49 mm; and AVR/AN with an AD of 50 mm. Propensity score matching was used to reduce bias.

Original languageEnglish (US)
Pages (from-to)2060-2069
Number of pages10
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number5
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


Dive into the research topics of 'Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: Validation of contemporary guidelines'. Together they form a unique fingerprint.

Cite this