Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Yoram Abramov*, Antonio R. Webb, Sylvia M. Botros, Roger P. Goldberg, Guillermo A. Ameer, Peter K. Sand

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.

Original languageEnglish (US)
Pages (from-to)1467-1470
Number of pages4
JournalFertility and Sterility
Issue number4
StatePublished - Mar 15 2011


  • Biomechanical properties
  • Young's modulus
  • estrogen deficiency
  • menopause
  • oophorectomy
  • tensile energy
  • tensile strength
  • vagina
  • wound healing

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


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