Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Yoram Abramov; Antonio R. Webb; Sylvia M. Botros; Roger P. Goldberg; Guillermo A. Ameer; Peter K. Sand

doi:10.1016/j.fertnstert.2010.08.001

Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Yoram Abramov^*, Antonio R. Webb, Sylvia M. Botros, Roger P. Goldberg, Guillermo A. Ameer, Peter K. Sand

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.

Original language	English (US)
Pages (from-to)	1467-1470
Number of pages	4
Journal	Fertility and Sterility
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2010.08.001
State	Published - Mar 15 2011

Funding

Supported by an institutional research grant from the Department of Obstetrics and Gynecology, North Shore University Health System , University of Chicago, Pritzker School of Medicine, Evanston, IL.

Keywords

Biomechanical properties
Young's modulus
estrogen deficiency
menopause
oophorectomy
tensile energy
tensile strength
vagina
wound healing

ASJC Scopus subject areas

Obstetrics and Gynecology
Reproductive Medicine

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10.1016/j.fertnstert.2010.08.001

Cite this

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title = "Effect of bilateral oophorectomy on wound healing of the rabbit vagina",

abstract = "We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.",

keywords = "Biomechanical properties, Young's modulus, estrogen deficiency, menopause, oophorectomy, tensile energy, tensile strength, vagina, wound healing",

author = "Yoram Abramov and Webb, {Antonio R.} and Botros, {Sylvia M.} and Goldberg, {Roger P.} and Ameer, {Guillermo A.} and Sand, {Peter K.}",

note = "Funding Information: Supported by an institutional research grant from the Department of Obstetrics and Gynecology, North Shore University Health System , University of Chicago, Pritzker School of Medicine, Evanston, IL. ",

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AU - Abramov, Yoram

AU - Webb, Antonio R.

AU - Botros, Sylvia M.

AU - Goldberg, Roger P.

AU - Ameer, Guillermo A.

AU - Sand, Peter K.

N1 - Funding Information: Supported by an institutional research grant from the Department of Obstetrics and Gynecology, North Shore University Health System , University of Chicago, Pritzker School of Medicine, Evanston, IL.

PY - 2011/3/15

Y1 - 2011/3/15

N2 - We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.

AB - We aimed to assess the effect of bilateral oophorectomy on vaginal wound healing in three groups of New Zealand White rabbits (24 rabbits each). Group 1 underwent bilateral oophorectomy, group 2 underwent a sham surgery, and group 3 served as control. Standardized vaginal tissue specimens were harvested and assessed for wound and scar surface area and tensiometric analysis before wounding, and sequentially thereafter, showing that vaginal wound closure, scar contraction, and recovery of biomechanical properties are significantly slower in oophorectomized rabbits.

KW - Biomechanical properties

KW - Young's modulus

KW - estrogen deficiency

KW - menopause

KW - oophorectomy

KW - tensile energy

KW - tensile strength

KW - vagina

KW - wound healing

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JO - Fertility and Sterility

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Effect of bilateral oophorectomy on wound healing of the rabbit vagina

Abstract

Funding

Keywords

ASJC Scopus subject areas

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