Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors: Case study

Babak Afsharipour, Sourav Chandra, William Z Rymer, Nina l Suresh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Spasticity, characterized by hyperreflexia, is a common motor impairment following hemispheric stroke. Botulinum toxin (BT) injections are widely used to reduce spasticity. BT acts by disrupting action potential propagation between a motor neuron and its innervated muscle fibers. Here we quantified the magnitude and time course of a BT injection on the stretch reflex responses, by analyzing the root mean squared amplitude of tap evoked surface EMG (sEMG) potentials from stroke affected biceps brachii (BB), before the BT injection and up to 18 weeks post-injection. We used a 16 × 8 sEMG electrode grid and mapped the tap-evoked potentials. We found, (a) the maximum reduction of the RMS EMG amplitude of the reflex response to occur six weeks post-BT injection and (b) a gradual recovery of the RMS EMG amplitude by 18 weeks post-injection. Unexpectedly, even at 18 weeks post injection, the tap-evoked reflex activity did not fully recover to its baseline (pre-injection recordings). These findings have a potential impact on the timing of BT administration for repeated injections.

LanguageEnglish (US)
Title of host publicationBiosystems and Biorobotics
PublisherSpringer International Publishing
Pages559-563
Number of pages5
DOIs
StatePublished - Jan 1 2019

Publication series

NameBiosystems and Biorobotics
Volume21
ISSN (Print)2195-3562
ISSN (Electronic)2195-3570

Fingerprint

Bioelectric potentials
Surface potential
Neurons
Muscle
Recovery
Electrodes
Fibers

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanical Engineering
  • Artificial Intelligence

Cite this

Afsharipour, B., Chandra, S., Rymer, W. Z., & Suresh, N. L. (2019). Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors: Case study. In Biosystems and Biorobotics (pp. 559-563). (Biosystems and Biorobotics; Vol. 21). Springer International Publishing. https://doi.org/10.1007/978-3-030-01845-0_112
Afsharipour, Babak ; Chandra, Sourav ; Rymer, William Z ; Suresh, Nina l. / Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors : Case study. Biosystems and Biorobotics. Springer International Publishing, 2019. pp. 559-563 (Biosystems and Biorobotics).
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Afsharipour, B, Chandra, S, Rymer, WZ & Suresh, NL 2019, Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors: Case study. in Biosystems and Biorobotics. Biosystems and Biorobotics, vol. 21, Springer International Publishing, pp. 559-563. https://doi.org/10.1007/978-3-030-01845-0_112

Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors : Case study. / Afsharipour, Babak; Chandra, Sourav; Rymer, William Z; Suresh, Nina l.

Biosystems and Biorobotics. Springer International Publishing, 2019. p. 559-563 (Biosystems and Biorobotics; Vol. 21).

Research output: Chapter in Book/Report/Conference proceedingChapter

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Afsharipour B, Chandra S, Rymer WZ, Suresh NL. Effect of botulinum toxin injections on stretch reflex responses of spastic elbow flexors in hemispheric stroke survivors: Case study. In Biosystems and Biorobotics. Springer International Publishing. 2019. p. 559-563. (Biosystems and Biorobotics). https://doi.org/10.1007/978-3-030-01845-0_112