Effect of buspirone on rat plasma prolactin levels and striatal dopamine turnover

H. Y. Meltzer*, M. Simonovic, V. S. Fang, G. A. Gudelsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Buspirone, an effective antianxiety compound, produced a dose-dependent, relatively prolonged increase in rat plasma prolactin (PRL) levels. The stimulation of PRL secretion by buspirone was additive with the effect of α-methyl-p-tyrosine (AMPT) or γ-butyrolactone. In vitro, buspirone itself had no effect on the release of PRL from rat pituitary glands but it blocked the inhibitory action of dopamine (DA). Buspirone also increased DA turnover in the striatum as measured by the AMPT-induced depletion of striatal DA levels. These results demonstrate the ability of buspirone to block pituitary and striatal DA receptors.

Original languageEnglish (US)
Pages (from-to)49-53
Number of pages5
JournalPsychopharmacology
Volume78
Issue number1
DOIs
StatePublished - Mar 1 1982

Keywords

  • Buspirone
  • Dopamine
  • Dopamine receptors
  • Prolactin

ASJC Scopus subject areas

  • Pharmacology

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