Effect of castration on dehydroepiandrosterone-induced hepatocarcinogenesis in male rats

Sambasiva Rao Musunuri*, P. Kashireddy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Dehydroepiandrosterone (DHEA), a peroxisome proliferator, is a hepatocarcinogen in male and female rats. The incidence of DHEA-induced hepatic tumors was much higher in males compared to females, although the peroxisome proliferative effect is similar in both sexes. In this study, we have evaluated the effect of castration in male rats on DHEA-induced hepatocarcinogenesis. Orchiectomy resulted in a significant reduction in hepatocellular carcinomas (15% in castrated rats versus 81% in control rats). However, the incidence of neoplastic nodules was comparable in both orchiectomized and control groups (84% versus 94% in orchiectomized and control groups, respectively). Sixty-two percent of livers in the control group contained tumors larger than 10 mm compared to 8% in the orchiectomized group. These findings indicate that testosterone promotes the growth of neoplastic lesions induced by DHEA.

Original languageEnglish (US)
Pages (from-to)1409-1411
Number of pages3
JournalAnticancer Research
Volume22
Issue number3
StatePublished - Aug 14 2002

Keywords

  • Castration
  • Dehydroepiandrosterone
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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