Effect of chlorpromazine on H-reflex recovery curves in normal subjects and schizophrenic patients

John Metz*, Henry H. Holcomb, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study sought to determine the effect of chlorpromazine (CPZ) on a physiological measure, the H-reflex recovery curve (HRRC) and to determine whether the effect is different in normal subjects and schizophrenic patients. Eleven normal control subjects and 14 patients were administered 12.5 and 25.0 mg CPZ by IM injection. On the average, HRRCs measured 90 min after the injections were lower compared to pre-injection levels in both groups, at both doses. In general, the higher dose was more effective in both groups. Half of the patients, however, failed to respond to 12.5 mg, indicating that some schizophrenics are less sensitive than normals to CPZ. These results indicate that excessive dopamine activity or sensitivity may underlie abnormally high HRRCs in unmedicated psychotic patients.

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalPsychopharmacology
Volume78
Issue number4
DOIs
StatePublished - Dec 1 1982

Keywords

  • Chlorpromazine
  • H-reflex
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

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