Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method

Sum a ̧n Sahai; Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0165-1781(81)90040-8

Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method

Sum a ̧n Sahai, Ramesh C. Arora, Herbert Y. Meltzer^*

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The effect of chlorpromazine treatment on platelet monoamine oxidase (MAO) activity was compared in platelets isolated by the Corash method, which harvests essentially all the platelets in a blood sample, and a single centrifugation method, which yields 45-65% of the platelets. A highly significant decrease in platelet MAO activity following chlorpromazine was found in platelets obtained from the same subjects by both methods. The decrease observed by the two methods was significantly correlated. These results indicate the degree of decrease in MAO activity associated with chlorpromazine is not due to isolation of a subpopulation of platelets with low MAO activity by the single centrifugation method.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Psychiatry Research
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(81)90040-8
State	Published - Oct 1981

Keywords

Corash method
Monoamine oxidase
chlorpromazine
neuroleptics
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(81)90040-8

Cite this

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title = "Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method",

abstract = "The effect of chlorpromazine treatment on platelet monoamine oxidase (MAO) activity was compared in platelets isolated by the Corash method, which harvests essentially all the platelets in a blood sample, and a single centrifugation method, which yields 45-65% of the platelets. A highly significant decrease in platelet MAO activity following chlorpromazine was found in platelets obtained from the same subjects by both methods. The decrease observed by the two methods was significantly correlated. These results indicate the degree of decrease in MAO activity associated with chlorpromazine is not due to isolation of a subpopulation of platelets with low MAO activity by the single centrifugation method.",

keywords = "Corash method, Monoamine oxidase, chlorpromazine, neuroleptics, schizophrenia",

author = "Sahai, {Sum a{\c }n} and Arora, {Ramesh C.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgments. Supported in part by USPHS MH-25,116and MH-30,059and by the State of Illinois Department of Mental Health. HYM is recipient of USPHS RCSA M H-47,808.",

year = "1981",

month = oct,

doi = "10.1016/0165-1781(81)90040-8",

language = "English (US)",

volume = "5",

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journal = "Psychiatry Research",

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T1 - Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method

AU - Sahai, Sum a ̧n

AU - Arora, Ramesh C.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Acknowledgments. Supported in part by USPHS MH-25,116and MH-30,059and by the State of Illinois Department of Mental Health. HYM is recipient of USPHS RCSA M H-47,808.

PY - 1981/10

Y1 - 1981/10

N2 - The effect of chlorpromazine treatment on platelet monoamine oxidase (MAO) activity was compared in platelets isolated by the Corash method, which harvests essentially all the platelets in a blood sample, and a single centrifugation method, which yields 45-65% of the platelets. A highly significant decrease in platelet MAO activity following chlorpromazine was found in platelets obtained from the same subjects by both methods. The decrease observed by the two methods was significantly correlated. These results indicate the degree of decrease in MAO activity associated with chlorpromazine is not due to isolation of a subpopulation of platelets with low MAO activity by the single centrifugation method.

AB - The effect of chlorpromazine treatment on platelet monoamine oxidase (MAO) activity was compared in platelets isolated by the Corash method, which harvests essentially all the platelets in a blood sample, and a single centrifugation method, which yields 45-65% of the platelets. A highly significant decrease in platelet MAO activity following chlorpromazine was found in platelets obtained from the same subjects by both methods. The decrease observed by the two methods was significantly correlated. These results indicate the degree of decrease in MAO activity associated with chlorpromazine is not due to isolation of a subpopulation of platelets with low MAO activity by the single centrifugation method.

KW - Corash method

KW - Monoamine oxidase

KW - chlorpromazine

KW - neuroleptics

KW - schizophrenia

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SN - 0165-1781

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JF - Psychiatry Research

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Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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