Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats

Peiwen Chen; Yushan Liu; Yanguo Hong

doi:10.1016/j.ejphar.2008.06.023

Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats

Peiwen Chen, Yushan Liu, Yanguo Hong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administration of morphine (20 μg) for 6 days, but not 2 days, significantly reduced the expression of BAM22-IR whereas i.t. administration of saline for 2 and 6 days did not alter the expression of BAM22-IR. The present study suggests that reduction of BAM22-IR in the spinal cord is involved in the development of morphine tolerance.

Original language	English (US)
Pages (from-to)	110-113
Number of pages	4
Journal	European Journal of Pharmacology
Volume	589
Issue number	1-3
DOIs	https://doi.org/10.1016/j.ejphar.2008.06.023
State	Published - Jul 28 2008
Externally published	Yes

Keywords

BAM22 (Bovine adrenal medulla 22)
Chronic morphine
Intrathecal
Spinal dorsal horn

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/j.ejphar.2008.06.023

Cite this

@article{27a671a81d8b4669810b5e397cd143ac,

title = "Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats",

abstract = "The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administration of morphine (20 μg) for 6 days, but not 2 days, significantly reduced the expression of BAM22-IR whereas i.t. administration of saline for 2 and 6 days did not alter the expression of BAM22-IR. The present study suggests that reduction of BAM22-IR in the spinal cord is involved in the development of morphine tolerance.",

keywords = "BAM22 (Bovine adrenal medulla 22), Chronic morphine, Intrathecal, Spinal dorsal horn",

author = "Peiwen Chen and Yushan Liu and Yanguo Hong",

year = "2008",

month = jul,

day = "28",

doi = "10.1016/j.ejphar.2008.06.023",

language = "English (US)",

volume = "589",

pages = "110--113",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1-3",

}

TY - JOUR

T1 - Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats

AU - Chen, Peiwen

AU - Liu, Yushan

AU - Hong, Yanguo

PY - 2008/7/28

Y1 - 2008/7/28

N2 - The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administration of morphine (20 μg) for 6 days, but not 2 days, significantly reduced the expression of BAM22-IR whereas i.t. administration of saline for 2 and 6 days did not alter the expression of BAM22-IR. The present study suggests that reduction of BAM22-IR in the spinal cord is involved in the development of morphine tolerance.

AB - The aim of the present study was to investigate the effects of chronic administration of morphine on the expression of an endogenous opioid peptide in the spinal dorsal horn. Bovine adrenal medulla 22-like immunoreactivity (BAM22-IR) was found in the superficial layers of the spinal cord. Intrathecal (i.t.) administration of morphine (20 μg) for 6 days, but not 2 days, significantly reduced the expression of BAM22-IR whereas i.t. administration of saline for 2 and 6 days did not alter the expression of BAM22-IR. The present study suggests that reduction of BAM22-IR in the spinal cord is involved in the development of morphine tolerance.

KW - BAM22 (Bovine adrenal medulla 22)

KW - Chronic morphine

KW - Intrathecal

KW - Spinal dorsal horn

UR - http://www.scopus.com/inward/record.url?scp=47549111491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47549111491&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2008.06.023

DO - 10.1016/j.ejphar.2008.06.023

M3 - Article

C2 - 18577380

AN - SCOPUS:47549111491

VL - 589

SP - 110

EP - 113

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -

Effect of chronic administration of morphine on the expression of bovine adrenal medulla 22-like immunoreactivity in the spinal cord of rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this