Effect of circadian phase on context and cued fear conditioning in C57BL/6J mice

Verónica S. Valentinuzzi, Daniel E. Kolker*, Martha Hotz Vitaterna, Elenice A.M. Ferrari, Joseph S. Takahashi, Fred W. Turek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We examined context-dependent and tone-cued fear conditioning during the activity and rest periods of C57BL/6J mice. Wheel-running activity was measured continuously as a marker of circadian phase. To control the effects of light on the response, the animals were kept in a skeleton photoperiod (two 15-min light pulses per day, indicating the beginning and the end of the day). Half the animals were trained and tested for context-dependent fear conditioning 2 h after the morning light pulse; the other half were trained and tested 2 h after the evening light pulse. Animals were tested every 24 h for 5 days to analyze the conditioned response and the rate of extinction. They were then trained for tone-cued fear conditioning at the same time and tested for 5 consecutive days. A significant difference between the morning and the evening groups was observed in the conditioning level and extinction rate of context-dependent fear conditioning, but not in tone-cued fear conditioning. These results suggest a modulating effect of the biological clock on the context fear-conditioning pathway.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalAnimal Learning and Behavior
Volume29
Issue number2
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Animal Science and Zoology
  • Psychology(all)
  • Behavioral Neuroscience

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