Effect of clozapine treatment on serotonin-2-receptor binding in the blood platelets of schizophrenic patients

Ramesh C. Arora, Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The effect of clozapine and typical neuroleptic drug treatment on platelet serotonim (5-HT2) binding kinetic constants (Kd, Bmax) was studied in schizophrenic patients. Both treatments increased Bnmx by a comparable amount, indicating increased numbers of 5-HT2 sites, although not all typical neuroleptic drugs were effective in this regard. Clozapine, but not typical neuroleptic drugs, increased Kd, indicating a lower affinity of the 5-HT2 sites for 5-HT. In a multiple regression model, low Bmax at baseline predicted poor outcome on Brief Psychiatric Rating Scale measures in the clozapine-treated patients but not the neuroleptic-treated patients.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalNeuropsychopharmacology
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1994

Keywords

  • Clozapine
  • Neuroleptic treatment
  • Platelet receptor binding
  • Schizophrenia
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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