Effect of d- and l-amphetamine on rat plasma prolactin levels

H. Y. Meltzer*, R. G. Fessler, M. Simonovic, J. Doherty, V. S. Fang

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Although d- and l-amphetamine had no effect on plasma prolactin levels in untreated male rats, both d- and l-amphetamine reversed the increase in plasma prolactin levels produced by reserpine and 5-hydroxytryptophan (5-HTP). Only d-amphetamine significantly reversed the effect of alpha-methylparatyrosine (AMPT) on plasma prolactin levels. This reversal is probably due to a direct or indirect dopamine agonist effect of amphetamine, rather than to an effect on norepinephrine. This conclusion is based on the finding that apomorphine, a direct-acting dopamine agonist, reversed the reserpine-induced increase in prolactin secretion, while clonidine, a direct-acting alpha-adrenergic agonist, potentiated the reserpine-induced stimulation of prolactin secretion. The effect of d-amphetamine on the increase in plasma prolactin levels produced by reserpine, 5-HTP, or AMPT was always greater than that of the l-isomer, suggesting that the d-isomer has a more profound effect on dopaminerelease or neuronal reuptake, or both, than l-amphetamine. Chronic administration of d-amphetamine prior to reserpine did not inhibit the ability of d-amphetamine to reverse the reserpine-induced increase in plasma prolactin. Chronic administration of AMPT did not enhance the ability of d-amphetamine to reverse the AMPT-induced increase in plasma prolactin.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalPsychopharmacology
Volume61
Issue number1
DOIs
StatePublished - Jan 1 1979

Keywords

  • 5-Hydroxytryptophan
  • Alpha-methylparatyrosine
  • Dopamine
  • Prolactin
  • Reserpine
  • Supersensitivity
  • Tolerance
  • d-Amphetamine
  • l-Amphetamine

ASJC Scopus subject areas

  • Pharmacology

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    Meltzer, H. Y., Fessler, R. G., Simonovic, M., Doherty, J., & Fang, V. S. (1979). Effect of d- and l-amphetamine on rat plasma prolactin levels. Psychopharmacology, 61(1), 63-69. https://doi.org/10.1007/BF00426812