Effect of Defibrination on Tumor Growth and Response to Chemotherapy

William D. DeWys, Hau C. Kwaan, Sudha Bathina

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Other investigators have demonstrated fibrin deposition in tumors. Experiments were therefore designed to test whether systemic defibrination would alter tumor growth or tumor response to chemotherapy with cyclophosphamide. Defibrination with Ancrod, a venom extract of Agkistrodon rhodostoma, did not significantly affect tumor sensitivity to chemotherapy. Similarly, defibrination plus fibrinolytic therapy with streptokinase did not affect responsiveness to cyclophosphamide. Long-term defibrination did not affect tumor growth. These results suggest three possible interpretations: (a) the coagulation system may not be important in tumor growth and response to chemotherapy; (b) adequate clearing of fibrin from the tumor was not accomplished in our experiments; or (c) other factors such as platelet deposition may be involved and platelet function was not inhibited by the therapies used in our experiments.

Original languageEnglish (US)
Pages (from-to)3584-3587
Number of pages4
JournalCancer Research
Volume36
Issue number10
StatePublished - Jan 1 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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