Effect of dehydration on interstitial pressures in the isolated dog lung

M. R. Glucksberg, J. Bhattacharya

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10 Scopus citations


We have determined the effect of dehydration on regional lung interstitial pressures. We stopped blood flow in the isolated blood-perfused lobe of dog lung at vascular pressure of ~ 4 cmH2O. Then we recorded interstitial pressures by micropuncture at alveolar junctions (Pjct), in perimicrovascular adventitia (Padv), and at the hilum (Phil). After base-line measurements, we ventilated the lobes with dry gas to decrease extravascular lung water content by 14 ± 5%. In one group (n = 10), at constant inflation pressure of 7 cmH2O, Pjct was 0.2 ± 0.8 and Padv was -1.5 ± 0.6 cmH2O. After dehydration the pressures fell to -5.0 ± 1.0 and -5.3 ± 1.3 cmH2O, respectively (P < 0.01), and the junction-to-advential gradient (Pjct-Padv) was abolished. In a second group (n = 6) a combination of dehydration and lung expansion with inflation pressure of 15 cmH2O further decreased Pjct and Padv to -7.3 ± 0.7 and -7.1 ± 0.7 cmH2O, respectively. Phil followed changes in Padv. Interstitial compliance was 0.6 at the junctions, 0.8 in adventitia, and 0.9 ml · cmH2O-1 · 100 g-1 wet lung at the hilum. We conclude, that perialveolar interstitial pressures may provide an important mechanism for prevention of lung dehydration.

Original languageEnglish (US)
Pages (from-to)839-845
Number of pages7
JournalJournal of Applied Physiology
Issue number2
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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