Effect of des-tyr-γ-endorphin in schizophrenia

H. Y. Meltzer, D. A. Busch, J. Lee, Y. Papacostas

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The overall clinical impression was that 2 of the 8 patients showed marked clinical improvement, 4 showed minimal to moderate improvement, and 2 showed no change. Improvement was mainly in the area of social functioning. Reports of delusions and hallucinations decreased. No extrapyramidal or other side effects were noted. After discontinuation DTγE, 6 of 8 patients showed deterioration. Considerably greater improvement was noted in these patients during the neuroleptic treatment period which followed DTγE. Platelet MAO activity decreased in 6 of the 8 patients during DTγE treatent. No change in serum prolactin levels was observed for up to 4 hours after injection of 1 mg DTγE.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalPsychopharmacology Bulletin
Issue number1
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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