Effect of desipramine treatment on 3H-imipramine binding in the blood platelets of depressed patients

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Platelet imipramine binding (IB) was studied in depressed patients before and after treatment with desipramine for 17-28 days. Administration of desipramine was associated with a significant increase in Bmax. There was a trend for an increase in Kd, but it did not reach statistical significance. The net result of the changes in Bmax and Kd was an increase in IB. There were significant correlations between the change in depression ratings and pretreatment Kd, as well as the change in Kd during treatment. These results suggest that decreased IB is not a trait-dependent marker, but a state-dependent marker for depression.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalBiological psychiatry
Volume23
Issue number4
DOIs
StatePublished - Feb 15 1988

ASJC Scopus subject areas

  • Biological Psychiatry

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