Effect of endothelin-1 on apoptosis, proliferation, and protein synthesis in cardiomyocytes of newborn albino rats

N. P. Mel'nikova, S. S. Timoshin*, L. J. Pelliniemi, E. Jokinen, E. Abdelwahid

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Five intraperitoneal injections of endothelin-1 (100 μg/kg) to newborn albino rats on days 2-6 of life did not change the number of nuclei expressing PCNA in the left-ventricular myocardium. The number of nucleoli, area and perimeter of cardiomyocytes (isolated by the method of alkaline dissociation) increased. The number of myocyte nuclei in the state of apoptosis (evaluated by the TUNEL method) increased significantly. Presumably, partial loss of cardiomyocytes as a result of apoptosis activation after treatment with endothelin-1 is compensated by increased size and transcription activity of remaining cardiomyocytes.

Original languageEnglish (US)
Pages (from-to)606-608
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume137
Issue number6
DOIs
StatePublished - Jun 2004

Keywords

  • Apoptosis
  • Endothelin
  • Myocardial morphogenesis
  • Proliferation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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