Effect of exercise on hormone sensitive lipase activity in rat adipocytes

J. A. McGarr, L. B. Oscai, J. Borensztajn

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12 Scopus citations


Hormone sensitive lipase activity was measured in adipocytes of rats subjected to a 12 wk program of treadmill running. Enzyme activity in the runners sacrificed immediately after exercise increased 2.5 fold (P<0.001) in tissue exposed to epinephrine and threefold (P<0.001) in tissue not exposed to epinephrine, when the results were expressed per gram of adipose tissue. Increases of almost the same magnitude were observed in runners sacrificed 24 h after their last bout of work. These significant increases in enzyme activity, however, were the result of a significant reduction in the size of cells in the epididymal fat pads of the exercisers compared with those of the freely eating sedementary animals (68.7 ± 2.7 μm vs. 82.0 ± 2.7 μm; P<0.01). When the results were expressed on a per cell basis, therefore, hormone sensitive lipase activity, assayed in the presence or absence of epinephrine, was unaffected by the exercise program. These results provide evidence that the lipolytic capacity of adipocytes of normal, untrained rats is sufficiently large to meet the increased demand for free fatty acids imposed by the exercise program without the need for an adaptive increase in enzyme activity.

Original languageEnglish (US)
Pages (from-to)385-388
Number of pages4
JournalAmerican Journal of Physiology
Issue number2
StatePublished - 1976

ASJC Scopus subject areas

  • Physiology (medical)


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