TY - JOUR
T1 - Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance
AU - Fortunato, John E.
AU - Wagoner, Ashley L.
AU - Harbinson, Rachel L.
AU - D'Agostino, Ralph B.
AU - Shaltout, Hossam A.
AU - Diz, Debra I.
N1 - Publisher Copyright:
Copyright © 2014 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Background: We hypothesized that orthostatic intolerance (OI) is associated with gastric dysrhythmias, nausea, and abdominal pain, which improves using fludrocortisone to treat OI. Methods: Patients (n=16, girls) with OI completed questionnaires before and after fludrocortisone treatment (age 14.8±2.8 years). Ten patients underwent electrogastrograms (EGGs) before fludrocortisone. Results: All EGGs showed gastric dysrhythmias. Fludrocortisone reduced mean scores as follows: nausea, 3.1±0.8 to 2.1±1.1 (P=0.016); dizziness, 3.0±1.0 to 2.2±1.1 (P=0.0371); abdominal pain, 2.8±1.3 to 1.9±1.4 (P=0.0063); flushing, 2.3±1.2 to 1.5±1.4 (P=0.0476); and missing school, 2.2±1.5 to 1.2±1.5 (P=0.0078). Conclusions: Chronic nausea and abdominal pain accompany OI and improve with OI treatment.
AB - Background: We hypothesized that orthostatic intolerance (OI) is associated with gastric dysrhythmias, nausea, and abdominal pain, which improves using fludrocortisone to treat OI. Methods: Patients (n=16, girls) with OI completed questionnaires before and after fludrocortisone treatment (age 14.8±2.8 years). Ten patients underwent electrogastrograms (EGGs) before fludrocortisone. Results: All EGGs showed gastric dysrhythmias. Fludrocortisone reduced mean scores as follows: nausea, 3.1±0.8 to 2.1±1.1 (P=0.016); dizziness, 3.0±1.0 to 2.2±1.1 (P=0.0371); abdominal pain, 2.8±1.3 to 1.9±1.4 (P=0.0063); flushing, 2.3±1.2 to 1.5±1.4 (P=0.0476); and missing school, 2.2±1.5 to 1.2±1.5 (P=0.0078). Conclusions: Chronic nausea and abdominal pain accompany OI and improve with OI treatment.
KW - Chronic unexplained nausea
KW - Dysautonomia
KW - Electrogastrogram
KW - Fludrocortisone
KW - Neurally mediated hypotension
KW - Postural orthostatic tachycardia syndrome
KW - Tilt table testing
UR - http://www.scopus.com/inward/record.url?scp=84925702217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925702217&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000000305
DO - 10.1097/MPG.0000000000000305
M3 - Article
C2 - 25222805
AN - SCOPUS:84925702217
SN - 0277-2116
VL - 59
SP - 39
EP - 43
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 1
ER -