Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.
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