Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

Herbert Y. Meltzer*, Steven M. Paul, Victor S. Fang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalPsychopharmacology
Volume51
Issue number2
DOIs
StatePublished - Jan 1 1977

Keywords

  • Butaclamol
  • Dopamine
  • Flupenthixol
  • Prolactin

ASJC Scopus subject areas

  • Pharmacology

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