Effect of high levels of film compression on surfactant transport

J. Morris*, E. P. Ingenito, L. Mark, R. D. Kamm, M. Johnson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A previously developed adsorption-limited model that describes the transport of lung surfactant to and from an air-liquid interface has been extended to allow for diffusion in the bulk phase. We used this model to compare to experimental data from Schurch [1989]. We find that high levels of film compression lead transiently to large changes in adsorption rate, desorption rate and diffusion constant, consistent with what might expected if a selected purification of the interface was occurring leading to DPPC enrichment of the interface. The collapse of the surfactant film that occurs during compression leads to a significant elevation of surfactant concentration immediately underlying the interface, consistent with the formation of a subsurface depot of surfactant.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint Dive into the research topics of 'Effect of high levels of film compression on surfactant transport'. Together they form a unique fingerprint.

Cite this