Effect of high levels of film compression on surfactant transport

J. Morris*, E. P. Ingenito, L. Mark, R. D. Kamm, M. Johnson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A previously developed adsorption-limited model that describes the transport of lung surfactant to and from an air-liquid interface has been extended to allow for diffusion in the bulk phase. We used this model to compare to experimental data from Schurch [1989]. We find that high levels of film compression lead transiently to large changes in adsorption rate, desorption rate and diffusion constant, consistent with what might expected if a selected purification of the interface was occurring leading to DPPC enrichment of the interface. The collapse of the surfactant film that occurs during compression leads to a significant elevation of surfactant concentration immediately underlying the interface, consistent with the formation of a subsurface depot of surfactant.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
Volume1
ISBN (Print)0780356756
StatePublished - Dec 1 1999
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Surface-Active Agents
Compaction
Surface active agents
Adsorption
Purification
Desorption
Air
Lung
Liquids

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Morris, J., Ingenito, E. P., Mark, L., Kamm, R. D., & Johnson, M. (1999). Effect of high levels of film compression on surfactant transport. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1). IEEE.
Morris, J. ; Ingenito, E. P. ; Mark, L. ; Kamm, R. D. ; Johnson, M. / Effect of high levels of film compression on surfactant transport. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999.
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Morris, J, Ingenito, EP, Mark, L, Kamm, RD & Johnson, M 1999, Effect of high levels of film compression on surfactant transport. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.

Effect of high levels of film compression on surfactant transport. / Morris, J.; Ingenito, E. P.; Mark, L.; Kamm, R. D.; Johnson, M.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1999.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - A previously developed adsorption-limited model that describes the transport of lung surfactant to and from an air-liquid interface has been extended to allow for diffusion in the bulk phase. We used this model to compare to experimental data from Schurch [1989]. We find that high levels of film compression lead transiently to large changes in adsorption rate, desorption rate and diffusion constant, consistent with what might expected if a selected purification of the interface was occurring leading to DPPC enrichment of the interface. The collapse of the surfactant film that occurs during compression leads to a significant elevation of surfactant concentration immediately underlying the interface, consistent with the formation of a subsurface depot of surfactant.

AB - A previously developed adsorption-limited model that describes the transport of lung surfactant to and from an air-liquid interface has been extended to allow for diffusion in the bulk phase. We used this model to compare to experimental data from Schurch [1989]. We find that high levels of film compression lead transiently to large changes in adsorption rate, desorption rate and diffusion constant, consistent with what might expected if a selected purification of the interface was occurring leading to DPPC enrichment of the interface. The collapse of the surfactant film that occurs during compression leads to a significant elevation of surfactant concentration immediately underlying the interface, consistent with the formation of a subsurface depot of surfactant.

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Morris J, Ingenito EP, Mark L, Kamm RD, Johnson M. Effect of high levels of film compression on surfactant transport. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. IEEE. 1999