Effect of Inosine on Contractile Force and High-Energy Phosphates in Ischemic Hearts

J. X. Thomas*, C. E. Jones

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The effects of intravenously infused inosine on myocardial contractile force (MCF) and high-energy phosphate content were studied in 17 open-chest, pentobarbital-anesthetized mongrel dogs following occlusion of small branches of the left anterior descending and circumflex coronary arteries. In 7 dogs, MCF was measured using strain gauge arches sutured in the center of the ischemic area (IMCF), in the periphery of the ischemic area (PIMCF), and in a nonischemic area (NIMCF). After the arteries were ligated and IMCF had stabilized, an infusion of either 50 ml of 50 mM inosine or saline was begun at a rate of 10 ml/min. Inosine infusion produced increases in IMCF, PIMCF, and NIMCF of 32, 41, and 42% of preinfusion levels, respectively. In an additional 10 dogs, adenosine triphosphate (ATP) and creatine phosphate (CP) content of the ischemic myocardium was determined at intervals prior to and following coronary arterial occlusion, during which time either inosine (n = 5) or normal saline (n = 5) was infused. The degradation of ATP or CP was not altered with inosine infusion as compared to the saline-infused group. It has been concluded from the above data that inosine significantly increases MCF in ischemic hearts and that this augmentation in MCF is not associated with alterations in levels of ATP or CP.

Original languageEnglish (US)
Pages (from-to)468-472
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume161
Issue number4
DOIs
StatePublished - Sep 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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