Abstract
Oxygen tension (PO2) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, ΔPO2 (i.e., hyperoxic PO2 minus baseline PO2) was computed. Compared to the conscious state, brain ΔPO2 increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension.
Original language | English (US) |
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Pages (from-to) | 116-118 |
Number of pages | 3 |
Journal | Neuroscience Letters |
Volume | 524 |
Issue number | 2 |
DOIs | |
State | Published - Aug 30 2012 |
Keywords
- Anesthesia
- Autoregulation
- Barrel cortex
- Hyperoxia
- Oxygen
- Rabbit
ASJC Scopus subject areas
- Neuroscience(all)