Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits

Daniil Aksenov; Joshua E. Eassa; Janesh Lakhoo; Alice Wyrwicz; Robert A Linsenmeier

doi:10.1016/j.neulet.2012.07.019

Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits

Daniil Aksenov, Joshua E. Eassa, Janesh Lakhoo, Alice Wyrwicz, Robert A Linsenmeier^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Oxygen tension (PO₂) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, ΔPO₂ (i.e., hyperoxic PO₂ minus baseline PO₂) was computed. Compared to the conscious state, brain ΔPO₂ increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension.

Original language	English (US)
Pages (from-to)	116-118
Number of pages	3
Journal	Neuroscience Letters
Volume	524
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2012.07.019
State	Published - Aug 30 2012

Keywords

Anesthesia
Autoregulation
Barrel cortex
Hyperoxia
Oxygen
Rabbit

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2012.07.019

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title = "Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits",

abstract = "Oxygen tension (PO2) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, ΔPO2 (i.e., hyperoxic PO2 minus baseline PO2) was computed. Compared to the conscious state, brain ΔPO2 increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension.",

keywords = "Anesthesia, Autoregulation, Barrel cortex, Hyperoxia, Oxygen, Rabbit",

author = "Daniil Aksenov and Eassa, {Joshua E.} and Janesh Lakhoo and Alice Wyrwicz and Linsenmeier, {Robert A}",

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AU - Linsenmeier, Robert A

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