Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits

Daniil Aksenov, Joshua E. Eassa, Janesh Lakhoo, Alice Wyrwicz, Robert A Linsenmeier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Oxygen tension (PO2) was measured in rabbit whisker barrel cortex using oxygen sensitive electrodes to investigate the impact of isoflurane anesthesia on oxygen autoregulation. Responses to 90s episodes of 100% oxygen inspiration were obtained from rabbits before anesthesia, and then when the animals were anesthetized with 0.5% or 1.5% isoflurane. For each episode, ΔPO2 (i.e., hyperoxic PO2 minus baseline PO2) was computed. Compared to the conscious state, brain ΔPO2 increased during anesthesia with 1.5% isoflurane (0.73 MAC) by an average of 116%, whereas 0.5% isoflurane produced an insignificant average increase of 31%. The results suggest that moderate levels of isoflurane impaired autoregulation of brain tissue oxygen tension.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalNeuroscience Letters
Volume524
Issue number2
DOIs
StatePublished - Aug 30 2012

Keywords

  • Anesthesia
  • Autoregulation
  • Barrel cortex
  • Hyperoxia
  • Oxygen
  • Rabbit

ASJC Scopus subject areas

  • Neuroscience(all)

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