Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

H. Y. Meltzer*, T. Kolakowska, A. Robertson, B. J. Tricou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalPsychopharmacology
Volume81
Issue number1
DOIs
StatePublished - Aug 1 1983

Keywords

  • Autoreceptor
  • Bromocriptine
  • Dopamine
  • Growth hormone
  • Prolactin
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology

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