Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

H. Y. Meltzer; T. Kolakowska; A. Robertson; B. J. Tricou

doi:10.1007/BF00439271

Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

H. Y. Meltzer^*, T. Kolakowska, A. Robertson, B. J. Tricou

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

Original language	English (US)
Pages (from-to)	37-41
Number of pages	5
Journal	Psychopharmacology
Volume	81
Issue number	1
DOIs	https://doi.org/10.1007/BF00439271
State	Published - Aug 1 1983

Keywords

Autoreceptor
Bromocriptine
Dopamine
Growth hormone
Prolactin
Schizophrenia

ASJC Scopus subject areas

Pharmacology

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10.1007/BF00439271

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abstract = "Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.",

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AU - Meltzer, H. Y.

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AU - Robertson, A.

AU - Tricou, B. J.

PY - 1983/8/1

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N2 - Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

AB - Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

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KW - Dopamine

KW - Growth hormone

KW - Prolactin

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Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

Abstract

Keywords

ASJC Scopus subject areas

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