TY - JOUR
T1 - Effect of Met-enkephalin and opioid antagonists on rat macrophages
AU - Radulovic, Jelena
AU - Dimitrijević, Mirjana
AU - Laban, Olgica
AU - Stanojević, Stanislava
AU - Vasiljević, Tatjana
AU - Kovačević-Jovanović, Vesna
AU - Marković, Branislav M.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.
AB - Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed direct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.
KW - AO rats
KW - DA rats
KW - HO release
KW - Met-enkephalin
KW - Opioid antagonists
KW - Rat peritoneal macrophages
UR - http://www.scopus.com/inward/record.url?scp=0028867675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028867675&partnerID=8YFLogxK
U2 - 10.1016/0196-9781(95)02003-F
DO - 10.1016/0196-9781(95)02003-F
M3 - Article
C2 - 8545240
AN - SCOPUS:0028867675
SN - 0196-9781
VL - 16
SP - 1209
EP - 1213
JO - Peptides
JF - Peptides
IS - 7
ER -