Effect of methadone on the biophysical profile

Helen E. Cejtin*, Anthony Mills, Eddie L. Swift

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


OBJECTIVE: To determine the effect of methadone on the biophysical profile. STUDY DESIGN: Sixteen narcotics-dependent gravidas on methadone maintenance were selected for the study. Biophysical profiles and nonstress tests (NSTs) were performed on women between 28 and 40 weeks' estimated gestational are before and two hours after methadone was given. The reactivity of the nonstress tests, biophysical profile scores and time needed to complete the biophysical profile before and after methadone dosing were compared. RESULTS: Significantly more NSTs were nonreactive after methadone (P < .001), and it took more time for the NST to become reactive (P <.01). Although it took longer for the modified biophysical profile to be completed after methadone dosing, with the mean time going from 3.8 to 19.8 minutes (P <.01), the scores were the same before and lifter methadone in 75% of the women, with the mean score not significantly different before or after methadone. CONCLUSION: Our results suggest that the modified biophysical profile is a clinically useful test in the methadone-maintained gravida.

Original languageEnglish (US)
Pages (from-to)819-822
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number11
StatePublished - Nov 1996


  • biophysical profile
  • fetal movement
  • methadone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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