Effect of muscle tension during tendon transfer on sarcomerogenesis in a rabbit model

Jan Fridén, Eva Pontén, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Sarcomere number change was investigated in an animal model of tendon transfer. In 9 adult New Zealand white rabbits, the flexor digitorum longus muscle was cut distally and transferred and woven into the tibialis anterior tendon. Ankles were then immobilized for 3 weeks in 75°flexion. Transferred flexor digitorum longus muscles were harvested and complete architectural analysis was performed. Sarcomere lengths were measured using laser diffraction. Serial sarcomere number in transferred flexor digitorum longus fibers was a strong function of the sarcomere length at the time of transfer. A highly significant negative correlation between these 2 parameters was approximated by a linear relationship. Based on this finding, we conclude that serial sarcomere number is significantly affected by the degree of stretch during the transfer itself. This could easily compromise the purpose of surgical tendon transfer by reducing the procedure to little more than a tenodesis. Copyright (C) 2000 by the American Society for Surgery of the Hand.

Original languageEnglish (US)
Pages (from-to)138-143
Number of pages6
JournalJournal of Hand Surgery
Volume25
Issue number1
DOIs
StatePublished - Jan 2000

Keywords

  • Muscle
  • Passive tension
  • Sarcomere length
  • Sarcomerogenesis
  • Tendon transfer

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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