Effect of nano-scale curvature on the intrinsic blood coagulation system

Takashi Kushida, Krishnendu Saha, Chandramouleeswaran Subramani, Vikas Nandwana, Vincent M. Rotello*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.

Original languageEnglish (US)
Pages (from-to)14484-14487
Number of pages4
Issue number23
StatePublished - Dec 7 2014
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science


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