Effect of nano-scale curvature on the intrinsic blood coagulation system

Takashi Kushida; Krishnendu Saha; Chandramouleeswaran Subramani; Vikas Nandwana; Vincent M. Rotello

doi:10.1039/c4nr04128c

Effect of nano-scale curvature on the intrinsic blood coagulation system

Takashi Kushida, Krishnendu Saha, Chandramouleeswaran Subramani, Vikas Nandwana, Vincent M. Rotello^*

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.

Original language	English (US)
Pages (from-to)	14484-14487
Number of pages	4
Journal	Nanoscale
Volume	6
Issue number	23
DOIs	https://doi.org/10.1039/c4nr04128c
State	Published - Dec 7 2014

ASJC Scopus subject areas

General Materials Science

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10.1039/c4nr04128c

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title = "Effect of nano-scale curvature on the intrinsic blood coagulation system",

abstract = "The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.",

author = "Takashi Kushida and Krishnendu Saha and Chandramouleeswaran Subramani and Vikas Nandwana and Rotello, \{Vincent M.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2014.",

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doi = "10.1039/c4nr04128c",

language = "English (US)",

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T1 - Effect of nano-scale curvature on the intrinsic blood coagulation system

AU - Kushida, Takashi

AU - Saha, Krishnendu

AU - Subramani, Chandramouleeswaran

AU - Nandwana, Vikas

AU - Rotello, Vincent M.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2014.

PY - 2014/12/7

Y1 - 2014/12/7

N2 - The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.

AB - The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.

UR - https://www.scopus.com/pages/publications/84908873226

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U2 - 10.1039/c4nr04128c

DO - 10.1039/c4nr04128c

M3 - Article

C2 - 25341004

AN - SCOPUS:84908873226

SN - 2040-3364

VL - 6

SP - 14484

EP - 14487

JO - Nanoscale

JF - Nanoscale

IS - 23

ER -

Effect of nano-scale curvature on the intrinsic blood coagulation system

Abstract

ASJC Scopus subject areas

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