Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients

H. Y. Meltzer; M. B. Duncavage; H. Jackman; R. C. Arora; B. J. Tricou; M. Young

doi:10.1176/ajp.139.10.1242

Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients

H. Y. Meltzer, M. B. Duncavage, H. Jackman, R. C. Arora, B. J. Tricou, M. Young

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The authors determined the platelet MAO activity of 57 psychotic patients after a placebo period and after 3-65 days of neuroleptic treatment. Platelet MAO activity significantly decreased in both men and women after neuroleptic treatment. The platelet MAO activity of neuroleptic-treated schizophrenic woman was significantly less than that of drug-free schizophrenic women, who did differ from normal women. There were trends in the same direction for the schizophrenic men. Previous studies that reported lower platelet MAO activity in neuroleptic-treated schizophrenic patients than in normal controls may have been influenced by this neuroleptic effect.

Original language	English (US)
Pages (from-to)	1242-1248
Number of pages	7
Journal	Unknown Journal
Volume	139
Issue number	10
DOIs	https://doi.org/10.1176/ajp.139.10.1242
State	Published - 1982

ASJC Scopus subject areas

Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1176/ajp.139.10.1242

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abstract = "The authors determined the platelet MAO activity of 57 psychotic patients after a placebo period and after 3-65 days of neuroleptic treatment. Platelet MAO activity significantly decreased in both men and women after neuroleptic treatment. The platelet MAO activity of neuroleptic-treated schizophrenic woman was significantly less than that of drug-free schizophrenic women, who did differ from normal women. There were trends in the same direction for the schizophrenic men. Previous studies that reported lower platelet MAO activity in neuroleptic-treated schizophrenic patients than in normal controls may have been influenced by this neuroleptic effect.",

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AU - Tricou, B. J.

AU - Young, M.

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AB - The authors determined the platelet MAO activity of 57 psychotic patients after a placebo period and after 3-65 days of neuroleptic treatment. Platelet MAO activity significantly decreased in both men and women after neuroleptic treatment. The platelet MAO activity of neuroleptic-treated schizophrenic woman was significantly less than that of drug-free schizophrenic women, who did differ from normal women. There were trends in the same direction for the schizophrenic men. Previous studies that reported lower platelet MAO activity in neuroleptic-treated schizophrenic patients than in normal controls may have been influenced by this neuroleptic effect.

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Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients

Abstract

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