Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients

H. Y. Meltzer, M. B. Duncavage, H. Jackman, R. C. Arora, B. J. Tricou, M. Young

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The authors determined the platelet MAO activity of 57 psychotic patients after a placebo period and after 3-65 days of neuroleptic treatment. Platelet MAO activity significantly decreased in both men and women after neuroleptic treatment. The platelet MAO activity of neuroleptic-treated schizophrenic woman was significantly less than that of drug-free schizophrenic women, who did differ from normal women. There were trends in the same direction for the schizophrenic men. Previous studies that reported lower platelet MAO activity in neuroleptic-treated schizophrenic patients than in normal controls may have been influenced by this neuroleptic effect.

Original languageEnglish (US)
Pages (from-to)1242-1248
Number of pages7
JournalUnknown Journal
Volume139
Issue number10
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Psychiatry and Mental health

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